Intestinal cholesterol absorption in the chyluria model
نویسندگان
چکیده
منابع مشابه
The Relationship Between Cholesterol Absorption and Intestinal Cholesterol Synthesis in the Diabetic Rat Model
The chylomicron remnant particle is thought to be particularly atherogenic and we have previously shown alterations in post-prandial lipoproteins which could contribute to their atherogenicity. Cholesterol metabolism is disturbed in diabetes, yet the effect of diabetes on intestinal cholesterol synthesis and absorption has rarely been investigated. The aim of this study was to examine cholester...
متن کاملDietary Phospholipids and Intestinal Cholesterol Absorption
Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption. Limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man. A number of biological mechanisms have been proposed in order to explain how PL in the gut lumen is able to affect chole...
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In subjects fed a cholesterol-free diet there are three possible sources of intestinal lymph cholesterol: a) mucosal synthesis; b) absorption of endogenous (biliary) cholesterol; and c) transudation of plasma lipoproteins into the lacteals of the intestinal wall. To test these possibilities, the extent of transudation was measured by means of [3H]beta-sitosterol administered intravenously as a ...
متن کاملIntestinal absorption of cholesterol by the nephrotic rat.
Exogenous cholesterol, absorbed from the intestinal tract, is transported into the blood by the lymph of the thoracic duct. By means of thoracic duct cannulation and subsequent lymph collection following stomach feeding of 100 mg. of cholesterol dissolved in olive oil, it was found that the nephrotic rat has a diminished rate of cholesterol absorption. This could not be ascribed to a deficiency...
متن کاملDevelopment and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption.
Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I, and CD36, whereas two ATP-binding cassette half transporters, ABCG5 and ABCG8, on apical membranes work together for cholesterol efflux back to ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1987
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)38602-8